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Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)

Identifieur interne : 000227 ( France/Analysis ); précédent : 000226; suivant : 000228

Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)

Auteurs : Alfonso J. Cruz-Jentoft [Espagne] ; Francesco Landi [Italie] ; Stéphane M. Schneider [France] ; Clemente Zú Iga [Mexique] ; Hidenori Arai [Japon] ; Yves Boirie [France] ; Liang-Kung Chen [Taïwan] ; Roger A. Fielding [États-Unis] ; Finbarr C. Martin [Royaume-Uni] ; Jean-Pierre Michel [Suisse] ; Cornel Sieber [Allemagne] ; Jeffrey R. Stout [États-Unis] ; Stephanie A. Studenski [États-Unis] ; Bruno Vellas [France] ; Jean Woo ; Mauro Zamboni [Italie] ; Tommy Cederholm [Suède]

Source :

RBID : PMC:4204661

Descripteurs français

English descriptors

Abstract

Objective: to examine the clinical evidence reporting the prevalence of sarcopenia and the effect of nutrition and exercise interventions from studies using the consensus definition of sarcopenia proposed by the European Working Group on Sarcopenia in Older People (EWGSOP).

Methods: PubMed and Dialog databases were searched (January 2000–October 2013) using pre-defined search terms. Prevalence studies and intervention studies investigating muscle mass plus strength or function outcome measures using the EWGSOP definition of sarcopenia, in well-defined populations of adults aged ≥50 years were selected.

Results: prevalence of sarcopenia was, with regional and age-related variations, 1–29% in community-dwelling populations, 14–33% in long-term care populations and 10% in the only acute hospital-care population examined. Moderate quality evidence suggests that exercise interventions improve muscle strength and physical performance. The results of nutrition interventions are equivocal due to the low number of studies and heterogeneous study design. Essential amino acid (EAA) supplements, including ∼2.5 g of leucine, and β-hydroxy β-methylbutyric acid (HMB) supplements, show some effects in improving muscle mass and function parameters. Protein supplements have not shown consistent benefits on muscle mass and function.

Conclusion: prevalence of sarcopenia is substantial in most geriatric settings. Well-designed, standardised studies evaluating exercise or nutrition interventions are needed before treatment guidelines can be developed. Physicians should screen for sarcopenia in both community and geriatric settings, with diagnosis based on muscle mass and function. Supervised resistance exercise is recommended for individuals with sarcopenia. EAA (with leucine) and HMB may improve muscle outcomes.


Url:
DOI: 10.1093/ageing/afu115
PubMed: 25241753
PubMed Central: 4204661


Affiliations:


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PMC:4204661

Le document en format XML

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<name sortKey="Zamboni, Mauro" sort="Zamboni, Mauro" uniqKey="Zamboni M" first="Mauro" last="Zamboni">Mauro Zamboni</name>
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<title xml:lang="en" level="a" type="main">Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)</title>
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<name sortKey="Cruz Jentoft, Alfonso J" sort="Cruz Jentoft, Alfonso J" uniqKey="Cruz Jentoft A" first="Alfonso J." last="Cruz-Jentoft">Alfonso J. Cruz-Jentoft</name>
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<addr-line>Servicio de Geriatría</addr-line>
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<name sortKey="Martin, Finbarr C" sort="Martin, Finbarr C" uniqKey="Martin F" first="Finbarr C." last="Martin">Finbarr C. Martin</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<name sortKey="Michel, Jean Pierre" sort="Michel, Jean Pierre" uniqKey="Michel J" first="Jean-Pierre" last="Michel">Jean-Pierre Michel</name>
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<nlm:aff id="af10">
<addr-line>Département de Réhabilitation et Gériatrie</addr-line>
,
<institution>Hôpitaux Universitaires de Genève-Suisse</institution>
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<addr-line>Geneva</addr-line>
,
<country>Switzerland</country>
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<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<name sortKey="Sieber, Cornel" sort="Sieber, Cornel" uniqKey="Sieber C" first="Cornel" last="Sieber">Cornel Sieber</name>
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<nlm:aff id="af11">
<institution>Institut for Biomedicine of Ageing, University Erlangen-Nürnberg</institution>
,
<addr-line>Erlangen</addr-line>
,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<name sortKey="Stout, Jeffrey R" sort="Stout, Jeffrey R" uniqKey="Stout J" first="Jeffrey R." last="Stout">Jeffrey R. Stout</name>
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<institution>Institute for Exercise Physiology and Wellness Research, University of Central Florida</institution>
,
<addr-line>Orlando, FL</addr-line>
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<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author>
<name sortKey="Studenski, Stephanie A" sort="Studenski, Stephanie A" uniqKey="Studenski S" first="Stephanie A." last="Studenski">Stephanie A. Studenski</name>
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<nlm:aff id="af13">
<addr-line>Division of Geriatric Medicine</addr-line>
,
<institution>University of Pittsburgh</institution>
,
<addr-line>Pittsburgh, PA</addr-line>
,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name>
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<nlm:aff id="af14">
<addr-line>Department of Geriatric Medicine</addr-line>
,
<institution>Inserm U558 Le Centre Hospitalier Universitaire de Toulouse (CHU) – Gérontopôle</institution>
,
<addr-line>Toulouse</addr-line>
,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Woo, Jean" sort="Woo, Jean" uniqKey="Woo J" first="Jean" last="Woo">Jean Woo</name>
<affiliation>
<nlm:aff id="af15">
<addr-line>Department of Medicine and Therapeutics, Prince of Wales, Hospital</addr-line>
,
<institution>Chinese University of Hong Kong</institution>
,
<addr-line>Hong Kong SAR</addr-line>
,
<country>The People's Republic of China</country>
</nlm:aff>
<wicri:noCountry code="nlm country">The People's Republic of China</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Zamboni, Mauro" sort="Zamboni, Mauro" uniqKey="Zamboni M" first="Mauro" last="Zamboni">Mauro Zamboni</name>
<affiliation wicri:level="1">
<nlm:aff id="af16">
<addr-line>Division of Geriatrics, Department of Medicine, University of Verona, Verona, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Geriatrics, Department of Medicine, University of Verona, Verona</wicri:regionArea>
<wicri:noRegion>Verona</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cederholm, Tommy" sort="Cederholm, Tommy" uniqKey="Cederholm T" first="Tommy" last="Cederholm">Tommy Cederholm</name>
<affiliation wicri:level="1">
<nlm:aff id="af17">
<addr-line>Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism</addr-line>
,
<institution>Uppsala University</institution>
,
<addr-line>Uppsala</addr-line>
,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Age and Ageing</title>
<idno type="ISSN">0002-0729</idno>
<idno type="eISSN">1468-2834</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging</term>
<term>Dietary Supplements</term>
<term>Exercise Therapy</term>
<term>Female</term>
<term>Geriatric Assessment</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity</term>
<term>Muscle Strength</term>
<term>Muscle, Skeletal (physiopathology)</term>
<term>Nutrition Assessment</term>
<term>Nutritional Status</term>
<term>Prevalence</term>
<term>Sarcopenia (diagnosis)</term>
<term>Sarcopenia (epidemiology)</term>
<term>Sarcopenia (physiopathology)</term>
<term>Sarcopenia (therapy)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Activité motrice</term>
<term>Adulte d'âge moyen</term>
<term>Compléments alimentaires</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Force musculaire</term>
<term>Humains</term>
<term>Muscles squelettiques (physiopathologie)</term>
<term>Mâle</term>
<term>Prévalence</term>
<term>Résultat thérapeutique</term>
<term>Sarcopénie ()</term>
<term>Sarcopénie (diagnostic)</term>
<term>Sarcopénie (physiopathologie)</term>
<term>Sarcopénie (épidémiologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Traitement par les exercices physiques</term>
<term>Vieillissement</term>
<term>État nutritionnel</term>
<term>Évaluation de l'état nutritionnel</term>
<term>Évaluation gériatrique</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Sarcopenia</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr">
<term>Sarcopénie</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Sarcopenia</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Muscles squelettiques</term>
<term>Sarcopénie</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Muscle, Skeletal</term>
<term>Sarcopenia</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Sarcopenia</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Sarcopénie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging</term>
<term>Dietary Supplements</term>
<term>Exercise Therapy</term>
<term>Female</term>
<term>Geriatric Assessment</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity</term>
<term>Muscle Strength</term>
<term>Nutrition Assessment</term>
<term>Nutritional Status</term>
<term>Prevalence</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Activité motrice</term>
<term>Adulte d'âge moyen</term>
<term>Compléments alimentaires</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Force musculaire</term>
<term>Humains</term>
<term>Mâle</term>
<term>Prévalence</term>
<term>Résultat thérapeutique</term>
<term>Sarcopénie</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Traitement par les exercices physiques</term>
<term>Vieillissement</term>
<term>État nutritionnel</term>
<term>Évaluation de l'état nutritionnel</term>
<term>Évaluation gériatrique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>
<bold>Objective:</bold>
to examine the clinical evidence reporting the prevalence of sarcopenia and the effect of nutrition and exercise interventions from studies using the consensus definition of sarcopenia proposed by the European Working Group on Sarcopenia in Older People (EWGSOP).</p>
<p>
<bold>Methods:</bold>
PubMed and Dialog databases were searched (January 2000–October 2013) using pre-defined search terms. Prevalence studies and intervention studies investigating muscle mass plus strength or function outcome measures using the EWGSOP definition of sarcopenia, in well-defined populations of adults aged ≥50 years were selected.</p>
<p>
<bold>Results:</bold>
prevalence of sarcopenia was, with regional and age-related variations, 1–29% in community-dwelling populations, 14–33% in long-term care populations and 10% in the only acute hospital-care population examined. Moderate quality evidence suggests that exercise interventions improve muscle strength and physical performance. The results of nutrition interventions are equivocal due to the low number of studies and heterogeneous study design. Essential amino acid (EAA) supplements, including ∼2.5 g of leucine, and β-hydroxy β-methylbutyric acid (HMB) supplements, show some effects in improving muscle mass and function parameters. Protein supplements have not shown consistent benefits on muscle mass and function.</p>
<p>
<bold>Conclusion:</bold>
prevalence of sarcopenia is substantial in most geriatric settings. Well-designed, standardised studies evaluating exercise or nutrition interventions are needed before treatment guidelines can be developed. Physicians should screen for sarcopenia in both community and geriatric settings, with diagnosis based on muscle mass and function. Supervised resistance exercise is recommended for individuals with sarcopenia. EAA (with leucine) and HMB may improve muscle outcomes.</p>
</div>
</front>
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</div1>
</back>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Japon</li>
<li>Mexique</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Suède</li>
<li>Taïwan</li>
<li>États-Unis</li>
</country>
</list>
<tree>
<noCountry>
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</noCountry>
<country name="Espagne">
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<country name="Italie">
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<country name="France">
<noRegion>
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<name sortKey="Boirie, Yves" sort="Boirie, Yves" uniqKey="Boirie Y" first="Yves" last="Boirie">Yves Boirie</name>
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   |wiki=    Wicri/Amérique
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   |type=    RBID
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